Coagulation phenotype of wild-type mice on different genetic backgrounds
نویسندگان
چکیده
منابع مشابه
Variegation of the Phenotype Induced by the Gata-1 Mutation in Mice of Different Genetic Backgrounds
Correspondent address: Anna Rita Migliaccio, Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Phone no: 0039-0649902690; Fax no: 0039-0649387143; e-mail: [email protected]. This study was supported by Ministero per la Ricerca Scientifica e Tecnologica, grant no RBNE0189JJ_003, RBNE015P72_003 and DM193, 2003; MURST (PRIN 2000, grant ...
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All mice harboring the X-linked Gata1low mutation in a predominantly CD1 background are born anemic and thrombocytopenic. They recover from anemia at 1 month of age but remain thrombocytopenic all their life and develop myelofibrosis, a syndrome similar to human idiopathic myelofibrosis, at 12 months. The effects of the genetic background on the myelofibrosis developed by Gata1low mice was asse...
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ژورنال
عنوان ژورنال: Laboratory Animals
سال: 2018
ISSN: 0023-6772,1758-1117
DOI: 10.1177/0023677218811059